Ontology highlight
ABSTRACT:
SUBMITTER: Fiskus W
PROVIDER: S-EPMC4172421 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Fiskus Warren W Saba Nakhle N Shen Min M Ghias Mondana M Liu Jinyun J Gupta Soumyasri Das SD Chauhan Lata L Rao Rekha R Gunewardena Sumedha S Schorno Kevin K Austin Christopher P CP Maddocks Kami K Byrd John J Melnick Ari A Huang Peng P Wiestner Adrian A Bhalla Kapil N KN
Cancer research 20140305 9
Chronic lymphocytic leukemia (CLL) exhibits high remission rates after initial chemoimmunotherapy, but with relapses with treatment, refractory disease is the most common outcome, especially in CLL with the deletion of chromosome 11q or 17p. In addressing the need of treatments for relapsed disease, we report the identification of an existing U.S. Food and Drug Administration-approved small-molecule drug to repurpose for CLL treatment. Auranofin (Ridaura) is approved for use in treating rheumato ...[more]