Ontology highlight
ABSTRACT:
SUBMITTER: Suits MD
PROVIDER: S-EPMC4175358 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Suits Michael D L MDL Pluvinage Benjamin B Law Adrienne A Liu Yan Y Palma Angelina S AS Chai Wengang W Feizi Ten T Boraston Alisdair B AB
The Journal of biological chemistry 20140806 39
For a subset of pathogenic microorganisms, including Streptococcus pneumoniae, the recognition and degradation of host hyaluronan contributes to bacterial spreading through the extracellular matrix and enhancing access to host cell surfaces. The hyaluronate lyase (Hyl) presented on the surface of S. pneumoniae performs this role. Using glycan microarray screening, affinity electrophoresis, and isothermal titration calorimetry we show that the N-terminal module of Hyl is a hyaluronan-specific car ...[more]