Dataset Information

Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing.

ABSTRACT: Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of "epidermal" electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management.

SUBMITTER: Hattori Y

PROVIDER: S-EPMC4177017 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing.

Hattori Yoshiaki Y Falgout Leo L Lee Woosik W Jung Sung-Young SY Poon Emily E Lee Jung Woo JW Na Ilyoun I Geisler Amelia A Sadhwani Divya D Zhang Yihui Y Su Yewang Y Wang Xiaoqi X Liu Zhuangjian Z Xia Jing J Cheng Huanyu H Webb R Chad RC Bonifas Andrew P AP Won Philip P Jeong Jae-Woong JW Jang Kyung-In KI Song Young Min YM Nardone Beatrice B Nodzenski Michael M Fan Jonathan A JA Huang Yonggang Y West Dennis P DP Paller Amy S AS Alam Murad M Yeo Woon-Hong WH Rogers John A JA

Advanced healthcare materials 20140326 10

Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly ...[more]

PMID: 24668927

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Project description:BackgroundAlthough the sequence of events leading to wound repair has been described at the cellular and, to a limited extent, at the protein level this process has yet to be fully elucidated. Genome wide transcriptional analysis tools promise to further define the global picture of this complex progression of events.Study designThis study was part of a placebo-controlled double-blind clinical trial in which basal cell carcinomas were treated topically with an immunomodifier--toll-like receptor 7 agonist: imiquimod. The fourteen patients with basal cell carcinoma in the placebo arm of the trial received placebo treatment consisting solely of vehicle cream. A skin punch biopsy was obtained immediately before treatment and at the end of the placebo treatment (after 2, 4 or 8 days). 17.5K cDNA microarrays were utilized to profile the biopsy material.ResultsFour gene signatures whose expression changed relative to baseline (before wound induction by the pre-treatment biopsy) were identified. The largest group was comprised predominantly of inflammatory genes whose expression was increased throughout the study. Two additional signatures were observed which included preferentially pro-inflammatory genes in the early post-treatment biopsies (2 days after pre-treatment biopsies) and repair and angiogenesis genes in the later (4 to 8 days) biopsies. The fourth and smallest set of genes was down-regulated throughout the study. Early in wound healing the expression of markers of both M1 and M2 macrophages were increased, but later M2 markers predominated.ConclusionThe initial response to a cutaneous wound induces powerful transcriptional activation of pro-inflammatory stimuli which may alert the host defense. Subsequently and in the absence of infection, inflammation subsides and it is replaced by angiogenesis and remodeling. Understanding this transition which may be driven by a change from a mixed macrophage population to predominantly M2 macrophages, may help the interpretation of the cellular and molecular events occurring in the microenvironment of serially biopsied tissues.

Dataset Information

Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing.

Publications

Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing.

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