Generation and characterization of an HIV-1 subtype C transmitted and early founder virus consensus sequence.
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ABSTRACT:
SUBMITTER: Killick M
PROVIDER: S-EPMC4179916 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
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Generation and characterization of an HIV-1 subtype C transmitted and early founder virus consensus sequence.
Killick Mark M Capovilla Alexio A Papathanasopoulos Maria A MA
AIDS research and human retroviruses 20140811 10
The tight bottleneck during HIV-1 transmission generally results in only a single virus variant being transmitted. Investigation of the HIV-1 envelope glycoprotein (Env) can identify vulnerabilities of transmitting viruses that can be targeted by vaccines designed to elicit protection against global HIV-1. This study generated an HIV-1 subtype C consensus transmitted and early founder virus Env (EnvFVC) after detailed sequence analysis of 1,894 env genes obtained from 80 acutely infected individ ...[more]
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