Ontology highlight
ABSTRACT:
SUBMITTER: Wang R
PROVIDER: S-EPMC4180415 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Chemical science 20141001 10
An artificial nucleic acid analogue capable of self-assembly into duplex merely through hydrophobic interactions is presented. The replacement of Watson-Crick hydrogen bonding with strictly hydrophobic interactions has the potential to confer new properties and facilitate the construction of complex DNA nanodevices. To study how the hydrophobic effect works during the self-assembly of nucleic acid bases, we have designed and synthesized a series of fluorinated nucleic acids (FNA) containing 3,5- ...[more]