Ontology highlight
ABSTRACT:
SUBMITTER: Papadopoulou A
PROVIDER: S-EPMC4181611 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Papadopoulou Anastasia A Gerdemann Ulrike U Katari Usha L UL Tzannou Ifigenia I Liu Hao H Martinez Caridad C Leung Kathryn K Carrum George G Gee Adrian P AP Vera Juan F JF Krance Robert A RA Brenner Malcolm K MK Rooney Cliona M CM Heslop Helen E HE Leen Ann M AM
Science translational medicine 20140601 242
It remains difficult to treat the multiplicity of distinct viral infections that afflict immunocompromised patients. Adoptive transfer of virus-specific T cells (VSTs) can be safe and effective, but such cells have been complex to prepare and limited in antiviral range. We now demonstrate the feasibility and clinical utility of rapidly generated single-culture VSTs that recognize 12 immunogenic antigens from five viruses (Epstein-Barr virus, adenovirus, cytomegalovirus, BK virus, and human herpe ...[more]