Ontology highlight
ABSTRACT:
SUBMITTER: Dave H
PROVIDER: S-EPMC5415312 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Dave Hema H Luo Min M Blaney J W JW Patel Shabnum S Barese Cecilia C Cruz Conrad Russell CR Shpall Elizabeth J EJ Bollard Catherine M CM Hanley Patrick J PJ
Molecular therapy. Methods & clinical development 20170308
Umbilical cord blood (CB) has emerged as an effective alternative donor source for hematopoietic stem cell transplantation. Despite this success, the prolonged duration of immune suppression following CB transplantation and the naiveté of CB T cells leave patients susceptible to viral infections. Adoptive transfer of ex vivo-expanded virus-specific T cells from CB is both feasible and safe. However, the manufacturing process of these cells is complicated, lengthy, and labor-intensive. We have no ...[more]