Ontology highlight
ABSTRACT:
SUBMITTER: Kuper J
PROVIDER: S-EPMC4182028 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Kuper Jochen J Braun Cathy C Elias Agnes A Michels Gudrun G Sauer Florian F Schmitt Dominik R DR Poterszman Arnaud A Egly Jean-Marc JM Kisker Caroline C
PLoS biology 20140930 9
The eukaryotic XPD helicase is an essential subunit of TFIIH involved in both transcription and nucleotide excision repair (NER). Mutations in human XPD are associated with several inherited diseases such as xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. We performed a comparative analysis of XPD from Homo sapiens and Chaetomium thermophilum (a closely related thermostable fungal orthologue) to decipher the different molecular prerequisites necessary for either transcription ...[more]