Ontology highlight
ABSTRACT:
SUBMITTER: Peissert S
PROVIDER: S-EPMC7125077 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Peissert Stefan S Sauer Florian F Grabarczyk Daniel B DB Braun Cathy C Sander Gudrun G Poterszman Arnaud A Egly Jean-Marc JM Kuper Jochen J Kisker Caroline C
Nature communications 20200403 1
The XPD helicase is a central component of the general transcription factor TFIIH which plays major roles in transcription and nucleotide excision repair (NER). Here we present the high-resolution crystal structure of the Arch domain of XPD with its interaction partner MAT1, a central component of the CDK activating kinase complex. The analysis of the interface led to the identification of amino acid residues that are crucial for the MAT1-XPD interaction. More importantly, mutagenesis of the Arc ...[more]