Ontology highlight
ABSTRACT:
SUBMITTER: Lee YJ
PROVIDER: S-EPMC4184966 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Lee Yan-Jiun YJ Kurra Yadagiri Y Yang Yanyan Y Torres-Kolbus Jessica J Deiters Alexander A Liu Wenshe R WR
Chemical communications (Cambridge, England) 20141101 86
A number of non-canonical amino acids (NCAAs) with unstrained olefins are genetically encoded using mutant pyrrolysyl-tRNA synthetase-tRNA(Pyl)(CUA) pairs. These NCAAs readily undergo inverse electron-demand Diels-Alder cycloadditions with tetrazine dyes, leading to selective labeling of proteins bearing these NCAAs in live cells. ...[more]