Protein unfolding by biological unfoldases: insights from modeling.
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ABSTRACT:
SUBMITTER: Wojciechowski M
PROVIDER: S-EPMC4190598 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Protein unfolding by biological unfoldases: insights from modeling.
Wojciechowski Michał M Szymczak Piotr P Carrión-Vázquez Mariano M Cieplak Marek M
Biophysical journal 20141001 7
The molecular determinants of the high efficiency of biological machines like unfoldases (e.g., the proteasome) are not well understood. We propose a model to study protein translocation into the chamber of biological unfoldases represented as a funnel. It is argued that translocation is a much faster way of unfolding a protein than end-to-end stretching, especially in a low-force regime, because it allows for a conformational freedom while concentrating local tension on consecutive regions of a ...[more]
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