Ontology highlight
ABSTRACT:
SUBMITTER: Yin J
PROVIDER: S-EPMC4196161 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Yin Jinlong J Park Gunwoo G Lee Jeong Eun JE Park Ju Young JY Kim Tae-Hoon TH Kim Youn-Jae YJ Lee Seung-Hoon SH Yoo Heon H Kim Jong Heon JH Park Jong Bae JB
Oncotarget 20140801 16
Glioma stemness has been recognized as the most important reason for glioma relapse and drug resistance. Differentiation of glioma stem cells (GSCs) has been implicated as a novel approach to target recurrent glioma. However, the detailed molecular mechanism involved in the differentiation of GSCs has not yet been elucidated. This study identified CPEB1 as the key modulator that induces the differentiation of GSCs at the post-transcriptional level. Gain and loss of function experiments showed th ...[more]