Ontology highlight
ABSTRACT:
SUBMITTER: Csorba K
PROVIDER: S-EPMC4196649 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Csorba Kinga K Chiriac Mircea Teodor MT Florea Florina F Ghinia Miruna Georgiana MG Licarete Emilia E Rados Andreea A Sas Alexandra A Vuta Vlad V Sitaru Cassian C
Journal of cellular and molecular medicine 20140805 9
Epidermolysis bullosa acquisita (EBA) is an autoimmune subepidermal blistering disease of mucous membranes and the skin caused by autoantibodies against collagen VII. In silico and wet laboratory epitope mapping studies revealed numerous distinct epitopes recognized by EBA patients' autoantibodies within the non-collagenous (NC)1 and NC2 domains of collagen VII. However, the distribution of pathogenic epitopes on collagen VII has not yet been described. In this study, we therefore performed an i ...[more]