Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies VII
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ABSTRACT: Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. Conclusion: Antibodies to GD2 evolved from highly specific germlines. Highly specific germlines may be critical in evading autoimmunity issues.
ORGANISM(S): Bos taurus Dermestes lardarius Mus musculus Sus scrofa domesticus Homo sapiens Human immunodeficiency virus 1 Oryctolagus cuniculus Trypanosoma cruzi Ovis aries Frangula alnus Pachymenia carnosa Quercus alba Rhodotorula Ceratonia siliqua Pandalus borealis Megathura crenulata Senegalia senegal Gallus gallus Bothrops moojeni Gossypium hirsutum Oncorhynchus nerka
PROVIDER: GSE100310 | GEO | 2017/08/25
SECONDARY ACCESSION(S): PRJNA391739
REPOSITORIES: GEO
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