Unknown

Dataset Information

0

Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture.


ABSTRACT: Stem cell population size is highly regulated across species and tissue types, and alterations are associated with premature tissue failure or cancer. We assessed whether the tumor suppressor and mediator of cell contact inhibition Nf2/merlin plays a role in governing the hematopoietic stem cell pool by stem cell-autonomous or niche-determined processes. Hematopoietic stem cells in Nf2-deficient mice were increased in number and demonstrated a marked shift in location to the circulation. These changes were entirely dependent on changes in the microenvironment, with a marked increase in trabecular bone and marrow vascularity associated with increased VEGF, but without cell-autonomous alterations in stem cell characteristics. Nf2/merlin is critical for maintaining normal structure and function of the hematopoietic stem cell niche. It limits both bone and vascular components, and our model suggests that it thereby constrains stem cell number and position.

SUBMITTER: Larsson J 

PROVIDER: S-EPMC4197168 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture.

Larsson Jonas J   Ohishi Masanobu M   Garrison Brian B   Aspling Marie M   Janzen Viktor V   Adams Gregor B GB   Curto Marcello M   McClatchey Andrea I AI   Schipani Ernestina E   Scadden David T DT  

Cell stem cell 20080801 2


Stem cell population size is highly regulated across species and tissue types, and alterations are associated with premature tissue failure or cancer. We assessed whether the tumor suppressor and mediator of cell contact inhibition Nf2/merlin plays a role in governing the hematopoietic stem cell pool by stem cell-autonomous or niche-determined processes. Hematopoietic stem cells in Nf2-deficient mice were increased in number and demonstrated a marked shift in location to the circulation. These c  ...[more]

Similar Datasets

| S-EPMC8382200 | biostudies-literature
| S-EPMC4447142 | biostudies-literature
| S-EPMC4302072 | biostudies-literature
| S-EPMC6525549 | biostudies-literature
| S-EPMC3929585 | biostudies-literature
| S-EPMC4615258 | biostudies-literature
| S-EPMC3754876 | biostudies-literature
| S-EPMC3033574 | biostudies-literature
| S-EPMC8318988 | biostudies-literature
| S-EPMC2064288 | biostudies-literature