Ontology highlight
ABSTRACT:
SUBMITTER: Schroeder FA
PROVIDER: S-EPMC4198064 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Schroeder F A FA Wang C C Van de Bittner G C GC Neelamegam R R Takakura W R WR Karunakaran A A Wey H Y HY Reis S A SA Gale J J Zhang Y L YL Holson E B EB Haggarty S J SJ Hooker J M JM
ACS chemical neuroscience 20140919 10
Histone deacetylase (HDAC) enzymes have been demonstrated as critical components in maintaining chromatin homeostasis, CNS development, and normal brain function. Evidence in mouse models links HDAC expression to learning, memory, and mood-related behaviors; small molecule HDAC inhibitor tool compounds have been used to demonstrate the importance of specific HDAC subtypes in modulating CNS-disease-related behaviors in rodents. So far, no direct evidence exists to understand the quantitative chan ...[more]