Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC4199391 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Chen Xiao X Bracht John R JR Goldman Aaron David AD Dolzhenko Egor E Clay Derek M DM Swart Estienne C EC Perlman David H DH Doak Thomas G TG Stuart Andrew A Amemiya Chris T CT Sebra Robert P RP Landweber Laura F LF
Cell 20140801 5
Programmed DNA rearrangements in the single-celled eukaryote Oxytricha trifallax completely rewire its germline into a somatic nucleus during development. This elaborate, RNA-mediated pathway eliminates noncoding DNA sequences that interrupt gene loci and reorganizes the remaining fragments by inversions and permutations to produce functional genes. Here, we report the Oxytricha germline genome and compare it to the somatic genome to present a global view of its massive scale of genome rearrange ...[more]