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Massive genomic rearrangement acquired in a single catastrophic event during cancer development - samples

ABSTRACT: Massive genomic rearrangement acquired in a single catastrophic event during cancer development

PROVIDER: EGAD00001000002 | EGA |

REPOSITORIES: EGA

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Massive genomic rearrangement acquired in a single catastrophic event during cancer development.

Stephens Philip J PJ Greenman Chris D CD Fu Beiyuan B Yang Fengtang F Bignell Graham R GR Mudie Laura J LJ Pleasance Erin D ED Lau King Wai KW Beare David D Stebbings Lucy A LA McLaren Stuart S Lin Meng-Lay ML McBride David J DJ Varela Ignacio I Nik-Zainal Serena S Leroy Catherine C Jia Mingming M Menzies Andrew A Butler Adam P AP Teague Jon W JW Quail Michael A MA Burton John J Swerdlow Harold H Carter Nigel P NP Morsberger Laura A LA Iacobuzio-Donahue Christine C Follows George A GA Green Anthony R AR Flanagan Adrienne M AM Stratton Michael R MR Futreal P Andrew PA Campbell Peter J PJ

Cell 20110101 1

Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These ...[more]

PMID: 21215367

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Project description:Comment on published article "Massive genomic rearrangement acquired in a single catastrophic event during cancer development." by Stephens, P.J., Greenman, C.D., Beiyuan, F., Yang, F., Bignell, G.R., Mudie, L.J., Pleasance, E.D., Lau, K.W., Beare, D., Stebbings, L.A., et al. (2011). Cell 144, 27-40. [PMID: 21215367]

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