Ontology highlight
ABSTRACT:
SUBMITTER: Stephens PJ
PROVIDER: S-EPMC3065307 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Stephens Philip J PJ Greenman Chris D CD Fu Beiyuan B Yang Fengtang F Bignell Graham R GR Mudie Laura J LJ Pleasance Erin D ED Lau King Wai KW Beare David D Stebbings Lucy A LA McLaren Stuart S Lin Meng-Lay ML McBride David J DJ Varela Ignacio I Nik-Zainal Serena S Leroy Catherine C Jia Mingming M Menzies Andrew A Butler Adam P AP Teague Jon W JW Quail Michael A MA Burton John J Swerdlow Harold H Carter Nigel P NP Morsberger Laura A LA Iacobuzio-Donahue Christine C Follows George A GA Green Anthony R AR Flanagan Adrienne M AM Stratton Michael R MR Futreal P Andrew PA Campbell Peter J PJ
Cell 20110101 1
Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These ...[more]