Ontology highlight
ABSTRACT:
SUBMITTER: Pardee TS
PROVIDER: S-EPMC4199870 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Pardee Timothy S TS Lee King K Luddy John J Maturo Claudia C Rodriguez Robert R Isom Scott S Miller Lance D LD Stadelman Kristin M KM Levitan Denise D Hurd David D Ellis Leslie R LR Harrelson Robin R Manuel Megan M Dralle Sarah S Lyerly Susan S Powell Bayard L BL
Clinical cancer research : an official journal of the American Association for Cancer Research 20140827 20
<h4>Purpose</h4>The lipoate derivative CPI-613 is a first-in-class agent that targets mitochondrial metabolism. This study determined the effects of CPI-613 on mitochondrial function and defined the MTD, pharmacokinetics, and safety in patients with relapsed or refractory hematologic malignancies.<h4>Experimental design</h4>Human leukemia cell lines were exposed to CPI-613 and mitochondrial function was assayed. A phase I trial was conducted in which CPI-613 was given as a 2-hour infusion on day ...[more]