Ontology highlight
ABSTRACT:
SUBMITTER: Egawa Y
PROVIDER: S-EPMC5991736 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Egawa Yuki Y Saigo Chiemi C Kito Yusuke Y Moriki Toshiaki T Takeuchi Tamotsu T
PloS one 20180607 6
Clear cell sarcoma (CCS) is an aggressive type of soft tissue tumor that is associated with high rates of metastasis. In the present study, we found that CPI-613, which targets tumorous mitochondrial energy metabolism, induced autophagosome formation followed by lysosome fusion in HS-MM CCS cells in vitro. Interestingly, CPI-613 along with chloroquine, which inhibits the fusion of autophagosomes with lysosomes, significantly induced necrosis of HS-MM CCS cell growth in vitro. Subsequently, we es ...[more]