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Visibly emissive and responsive extended 6-aza-uridines.

ABSTRACT: A family of extended 5-modified-6-aza-uridines was obtained via Suzuki coupling reactions with a common brominated precursor. Extending the conjugated-6-aza-uridines with substituted aryl rings increases the push-pull interactions yielding enhanced bathochromic shifts and solvatochromism compared to the parent nucleosides. For example, the methoxy substituted derivative 1d displays ?max abs around 375 nm, with visible emission maxima at 486 nm (? = 0.74) and 525 nm (? = 0.02) in dioxane and water, respectively.

SUBMITTER: Hopkins PA

PROVIDER: S-EPMC4201329 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Visibly emissive and responsive extended 6-aza-uridines.

Hopkins Patrycja A PA Sinkeldam Renatus W RW Tor Yitzhak Y

Organic letters 20141006 20

A family of extended 5-modified-6-aza-uridines was obtained via Suzuki coupling reactions with a common brominated precursor. Extending the conjugated-6-aza-uridines with substituted aryl rings increases the push-pull interactions yielding enhanced bathochromic shifts and solvatochromism compared to the parent nucleosides. For example, the methoxy substituted derivative 1d displays λmax abs around 375 nm, with visible emission maxima at 486 nm (Φ = 0.74) and 525 nm (Φ = 0.02) in dioxane and wate ...[more]

PMID: 25285451

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