Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression.
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ABSTRACT:
SUBMITTER: Uzan B
PROVIDER: S-EPMC4203358 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression.
Uzan Benjamin B Poglio Sandrine S Gerby Bastien B Wu Ching-Lien CL Gross Julia J Armstrong Florence F Calvo Julien J Cahu Xavier X Deswarte Caroline C Dumont Florent F Passaro Diana D Besnard-Guérin Corinne C Leblanc Thierry T Baruchel André A Landman-Parker Judith J Ballerini Paola P Baud Véronique V Ghysdael Jacques J Baleydier Frédéric F Porteu Francoise F Pflumio Francoise F
EMBO molecular medicine 20140406 6
Development of novel therapies is critical for T-cell acute leukaemia (T-ALL). Here, we investigated the effect of inhibiting the MAPK/MEK/ERK pathway on T-ALL cell growth. Unexpectedly, MEK inhibitors (MEKi) enhanced growth of 70% of human T-ALL cell samples cultured on stromal cells independently of NOTCH activation and maintained their ability to propagate in vivo. Similar results were obtained when T-ALL cells were cultured with ERK1/2-knockdown stromal cells or with conditioned medium from ...[more]
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