Ontology highlight
ABSTRACT:
SUBMITTER: Hubner IA
PROVIDER: S-EPMC420398 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Hubner Isaac A IA Oliveberg Mikael M Shakhnovich Eugene I EI
Proceedings of the National Academy of Sciences of the United States of America 20040518 22
In this study, we explore nucleation and the transition state ensemble of the ribosomal protein S6 using a Monte Carlo (MC) Go model in conjunction with restraints from experiment. The results are analyzed in the context of extensive experimental and evolutionary data. The roles of individual residues in the folding nucleus are identified, and the order of events in the S6 folding mechanism is explored in detail. Interpretation of our results agrees with, and extends the utility of, experiments ...[more]