Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1.
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ABSTRACT:
SUBMITTER: Ramos A
PROVIDER: S-EPMC4204764 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
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Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1.
Ramos Adriana A Rodríguez-Seoane Carmen C Rosa Isaac I Trossbach Svenja V SV Ortega-Alonso Alfredo A Tomppo Liisa L Ekelund Jesper J Veijola Juha J Järvelin Marjo-Riitta MR Alonso Jana J Veiga Sonia S Sawa Akira A Hennah William W García Angel A Korth Carsten C Requena Jesús R JR
Human molecular genetics 20140616 22
In a large Scottish pedigree, disruption of the gene coding for DISC1 clearly segregates with major depression, schizophrenia and related mental conditions. Thus, study of DISC1 may provide a clue to understand the biology of major mental illness. A neuropeptide precursor VGF has potent antidepressant effects and has been reportedly associated with bipolar disorder. Here we show that DISC1 knockdown leads to a reduction of VGF, in neurons. VGF is also downregulated in the cortices from sporadic ...[more]
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