Ontology highlight
ABSTRACT:
SUBMITTER: Honek J
PROVIDER: S-EPMC4205611 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Honek Jennifer J Seki Takahiro T Iwamoto Hideki H Fischer Carina C Li Jingrong J Lim Sharon S Samani Nilesh J NJ Zang Jingwu J Cao Yihai Y
Proceedings of the National Academy of Sciences of the United States of America 20140930 41
Mechanisms underlying age-related obesity and insulin resistance are generally unknown. Here, we report age-related adipose vascular changes markedly modulated fat mass, adipocyte functions, blood lipid composition, and insulin sensitivity. Notably, VEGF expression levels in various white adipose tissues (WATs) underwent changes uninterruptedly in different age populations. Anti-VEGF and anti- VEGF receptor 2 treatment in different age populations showed marked variations of vascular regression, ...[more]