Ontology highlight
ABSTRACT:
SUBMITTER: Kuo TC
PROVIDER: S-EPMC4208311 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Kuo Tse-Chun TC Chen Chun-Ting CT Baron Desiree D Onder Tamer T TT Loewer Sabine S Almeida Sandra S Weismann Cara M CM Xu Ping P Houghton Jean-Marie JM Gao Fen-Biao FB Daley George Q GQ Doxsey Stephen S
Nature cell biology 20110911 10
The midbody is a singular organelle formed between daughter cells during cytokinesis and required for their final separation. Midbodies persist in cells long after division as midbody derivatives (MB(d)s), but their fate is unclear. Here we show that MB(d)s are inherited asymmetrically by the daughter cell with the older centrosome. They selectively accumulate in stem cells, induced pluripotent stem cells and potential cancer 'stem cells' in vivo and in vitro. MB(d) loss accompanies stem-cell di ...[more]