Dataset Information

Tumor immune evasion mediated through IRGQ-directed autophagy

ABSTRACT: SurfaceOME of IRGQ WT and KO 8988T cells under basal conditions

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Lina Herhaus

LAB HEAD: Lina Herhaus

PROVIDER: PXD045259 | Pride | 2024-11-01

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	20200710_MHO_LH_MembraneOME_8988T_KO_01.raw	Raw
	20200710_MHO_LH_MembraneOME_8988T_KO_02.raw	Raw
	20200710_MHO_LH_MembraneOME_8988T_KO_Biotin_01.raw	Raw
	20200710_MHO_LH_MembraneOME_8988T_KO_Biotin_02.raw	Raw
	20200710_MHO_LH_MembraneOME_8988T_KO_Biotin_03.raw	Raw

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Publications

IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion.

Herhaus Lina L Gestal-Mato Uxía U Eapen Vinay V VV Mačinković Igor I Bailey Henry J HJ Prieto-Garcia Cristian C Misra Mohit M Jacomin Anne-Claire AC Ammanath Aparna Viswanathan AV Bagarić Ivan I Michaelis Jolina J Vollrath Joshua J Bhaskara Ramachandra M RM Bündgen Georg G Covarrubias-Pinto Adriana A Husnjak Koraljka K Zöller Jonathan J Gikandi Ajami A Ribičić Sara S Bopp Tobias T van der Heden van Noort Gerbrand J GJ Langer Julian D JD Weigert Andreas A Harper J Wade JW Mancias Joseph D JD Dikic Ivan I

Cell 20241021

The autophagy-lysosome system directs the degradation of a wide variety of cargo and is also involved in tumor progression. Here, we show that the immunity-related GTPase family Q protein (IRGQ), an uncharacterized protein to date, acts in the quality control of major histocompatibility complex class I (MHC class I) molecules. IRGQ directs misfolded MHC class I toward lysosomal degradation through its binding mode to GABARAPL2 and LC3B. In the absence of IRGQ, free MHC class I heavy chains do no ...[more]

PMID: 39481378

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