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ABSTRACT:
SUBMITTER: Stolley RM
PROVIDER: S-EPMC4208422 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
European journal of organic chemistry 20110701 20-21
A variety of bicyclic <i>N</i>,<i>N</i>-disubstituted 2-aminopyridines have been prepared from diynes and cyanamides by nickel-catalyzed [2+2+2] cycloaddition reactions. The reactions proceeded at room temperature with low catalyst loading to afford 2-aminopyridines in good to excellent yields. The method is amenable to both internal and terminal diynes and proceeds in a regioselective manner. A number of cyanamides with diverse functional group tolerance were used. The intermolecular version em ...[more]