Synthetic polymers active against Clostridium difficile vegetative cell growth and spore outgrowth.
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ABSTRACT:
SUBMITTER: Liu R
PROVIDER: S-EPMC4210120 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
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Synthetic polymers active against Clostridium difficile vegetative cell growth and spore outgrowth.
Liu Runhui R Suárez Jose M JM Weisblum Bernard B Gellman Samuel H SH McBride Shonna M SM
Journal of the American Chemical Society 20141003 41
Nylon-3 polymers (poly-β-peptides) have been investigated as synthetic mimics of host-defense peptides in recent years. These polymers are attractive because they are much easier to synthesize than are the peptides themselves, and the polymers resist proteolysis. Here we describe in vitro analysis of selected nylon-3 copolymers against Clostridium difficile, an important nosocomial pathogen that causes highly infectious diarrheal disease. The best polymers match the human host-defense peptide LL ...[more]
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