Ontology highlight
ABSTRACT:
SUBMITTER: Sailland J
PROVIDER: S-EPMC4210291 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Sailland Juliette J Tribollet Violaine V Forcet Christelle C Billon Cyrielle C Barenton Bruno B Carnesecchi Julie J Bachmann Alice A Gauthier Karine Cécile KC Yu Shan S Giguère Vincent V Chan Franky L FL Vanacker Jean-Marc JM
Proceedings of the National Academy of Sciences of the United States of America 20141006 42
Several physiopathological processes require orientated cellular migration. This phenomenon highly depends on members of the RHO family of GTPases. Both excessive and deficient RHO activity impair directional migration. A tight control is thus exerted on these proteins through the regulation of their activation and of their stability. Here we show that the estrogen-related receptor α (ERRα) directly activates the expression of TNFAIP1, the product of which [BTB/POZ domain-containing adapter for ...[more]