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Sinulolides A-H, new cyclopentenone and butenolide derivatives from soft coral Sinularia sp.

ABSTRACT: Eight new compounds, sinulolides A-H (1-8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were determined on the basis of electronic circular dichroism (ECD) data analysis. Compounds 5 and 10 exhibited moderate effects for the inhibition of NF-κB activation.

SUBMITTER: Yang B

PROVIDER: S-EPMC4210901 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Sinulolides A-H, new cyclopentenone and butenolide derivatives from soft coral Sinularia sp.

Yang Bin B Wei Xiaoyi X Huang Jingxia J Lin Xiuping X Liu Juan J Liao Shengrong S Wang Junfeng J Zhou Xuefeng X Wang Lishu L Liu Yonghong Y

Marine drugs 20141023 10

Eight new compounds, sinulolides A-H (1-8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were determined on the basis of electronic circular dichroism (ECD) data analysis. Compounds 5 and 10 exhibited moderate effects for the inhibition of NF-κB activation. ...[more]

PMID: 25342460

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