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Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo.

ABSTRACT: Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide (1), (E,E,E)-6,10,14-trimethyl-3-methylene-cis-3?,4,5,8,9,12,13,15?-octahydrocyclo tetradeca[?]furan-2(3H)-one (3), and denticulatolide (4), were isolated from the Bornean soft coral Sinularia sp. Compounds 2 and 4 showed potential anti-inflammatory activities against lipopolysaccharide-stimulated RAW 264.7 with IC50 values less than 6.25 µg/mL and anticancer activity against HL60 cell lines. The compounds' mechanisms of action were investigated via the Western blot evaluation of their protein markers. These activities could be attributed to the presence of tertiary methyl at C-8 and the compounds' 3D configurations.

SUBMITTER: Kamada T

PROVIDER: S-EPMC5923386 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo.

Kamada Takashi T Kang Min-Cheol MC Phan Chin-Soon CS Zanil Intan Irna II Jeon You-Jin YJ Vairappan Charles S CS

Marine drugs 20180321 4

Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide (1), (E,E,E)-6,10,14-trimethyl-3-methylene-cis-3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca[β]furan-2(3H)-one (3), and denticulatolide (4), were isolated from the Bornean soft coral Sinularia sp. Compounds 2 and 4 showed poten ...[more]

PMID: 29561805

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