Monitoring the efficacy of dendritic cell vaccination by early detection of (99m) Tc-HMPAO-labelled CD4(+) T cells.
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ABSTRACT:
SUBMITTER: Sharif-Paghaleh E
PROVIDER: S-EPMC4211358 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
Monitoring the efficacy of dendritic cell vaccination by early detection of (99m) Tc-HMPAO-labelled CD4(+) T cells.
Sharif-Paghaleh Ehsan E Leech John J Sunassee Kavitha K Ali Niwa N Sagoo Pervinder P Lechler Robert I RI Smyth Lesley A LA Lombardi Giovanna G Mullen Gregory E GE
European journal of immunology 20140414 7
DC vaccines have been used to induce tumour-specific cytotoxic T cells . However, this approach to cancer immunotherapy has had limited success. To be successful, injected DCs need to migrate to the LNs where they can stimulate effector T cells . We and others have previously demonstrated by MRI that tumour antigen-pulsed-DCs labelled ex vivo with superparamagnetic iron oxide nanoparticles migrated to the draining LNs and are capable of activating antigen-specific T cells . The results from our ...[more]
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