Ontology highlight
ABSTRACT:
SUBMITTER: Ruzzo A
PROVIDER: S-EPMC4220280 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Ruzzo Annamaria A Graziano Francesco F Galli Fabio F Giacomini Elisa E Floriani Irene I Galli Francesca F Rulli Eliana E Lonardi Sara S Ronzoni Monica M Massidda Bruno B Zagonel Vittorina V Pella Nicoletta N Mucciarini Claudia C Labianca Roberto R Ionta Maria Teresa MT Veltri Enzo E Sozzi Pietro P Barni Sandro S Ricci Vincenzo V Foltran Luisa L Nicolini Mario M Biondi Edoardo E Bramati Annalisa A Turci Daniele D Lazzarelli Silvia S Verusio Claudio C Bergamo Francesca F Sobrero Alberto A Frontini Luciano L Magnani Mauro M
Scientific reports 20141105
We investigated 17 polymorphisms in 11 genes (TS, MTHFR, ERCC1, XRCC1, XRCC3, XPD, GSTT1, GSTP1, GSTM1, ABCC1, ABCC2) for their association with the toxicity of fluoropyrimidines and oxaliplatin in colorectal cancer patients enrolled in a prospective randomized trial of adjuvant chemotherapy. The TOSCA Italian adjuvant trial was conducted in high-risk stage II-III colorectal cancer patients treated with 6 or 3 months of either FOLFOX-4 or XELOX adjuvant chemotherapy. In the concomitant ancillary ...[more]