Ontology highlight
ABSTRACT:
SUBMITTER: Durham NM
PROVIDER: S-EPMC4220939 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Durham Nicholas M NM Nirschl Christopher J CJ Jackson Christopher M CM Elias Jimmy J Kochel Christina M CM Anders Robert A RA Drake Charles G CG
PloS one 20141105 11
Lymphocyte Activation Gene - 3 (LAG-3) is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. However, the molecular mechanisms underlying LAG-3's function are generally unknown. Using a model in which LAG-3 blockade or absence reliably augmented homeostatic proliferation in vivo, we found that IL-2 and STAT5 are critical for LAG-3 function. Similarly, LAG-3 blockade was ineffective in the absence of regulatory T-cells (Treg), suggesting an important role for LAG ...[more]