Ontology highlight
ABSTRACT:
SUBMITTER: Triebel F
PROVIDER: S-EPMC2187904 | biostudies-other | 1990 May
REPOSITORIES: biostudies-other
Triebel F F Jitsukawa S S Baixeras E E Roman-Roman S S Genevee C C Viegas-Pequignot E E Hercend T T
The Journal of experimental medicine 19900501 5
We have identified a novel human gene of the Ig superfamily, designated LAG-3. Expression of this gene is undetectable in resting PBL, while it is found (a 2-kb message) in activated T and NK cells. The LAG-3 gene includes eight exons; the corresponding cDNA encodes a 498-amino acid membrane protein with four extracellular IgSF domains. The first one belongs to the V-SET; it is particular since it includes an extra loop in the middle of the domain and an unusual intrachain disulphide bridge. The ...[more]