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In vivo tissue-wide synchronization of mitochondrial metabolic oscillations.

ABSTRACT: Little is known about the spatiotemporal coordination of mitochondrial metabolism in multicellular organisms in situ. Using intravital microscopy in live animals, we report that mitochondrial metabolism undergoes rapid and periodic oscillations under basal conditions. Notably, mitochondria in vivo behave as a network of functionally coupled oscillators, which maintain a high level of coordination throughout the tissue via the activity of gap junctions. These findings reveal a unique aspect of the relationship between tissue architecture and self-organization of mitochondrial metabolism in vivo.

SUBMITTER: Porat-Shliom N

PROVIDER: S-EPMC4223640 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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In vivo tissue-wide synchronization of mitochondrial metabolic oscillations.

Porat-Shliom Natalie N Chen Yun Y Tora Muhibullah M Shitara Akiko A Masedunskas Andrius A Weigert Roberto R

Cell reports 20141016 2

Little is known about the spatiotemporal coordination of mitochondrial metabolism in multicellular organisms in situ. Using intravital microscopy in live animals, we report that mitochondrial metabolism undergoes rapid and periodic oscillations under basal conditions. Notably, mitochondria in vivo behave as a network of functionally coupled oscillators, which maintain a high level of coordination throughout the tissue via the activity of gap junctions. These findings reveal a unique aspect of th ...[more]

PMID: 25373899

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