Ontology highlight
ABSTRACT:
SUBMITTER: Porat-Shliom N
PROVIDER: S-EPMC4223640 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Porat-Shliom Natalie N Chen Yun Y Tora Muhibullah M Shitara Akiko A Masedunskas Andrius A Weigert Roberto R
Cell reports 20141016 2
Little is known about the spatiotemporal coordination of mitochondrial metabolism in multicellular organisms in situ. Using intravital microscopy in live animals, we report that mitochondrial metabolism undergoes rapid and periodic oscillations under basal conditions. Notably, mitochondria in vivo behave as a network of functionally coupled oscillators, which maintain a high level of coordination throughout the tissue via the activity of gap junctions. These findings reveal a unique aspect of th ...[more]