Dataset Information

Selective deposition of a gadolinium(III) cluster in a hole opening of single-wall carbon nanohorn.

ABSTRACT: Selective synthesis of particles of angstrom to nanometer size consisting of one to many metal atoms is instrumental in various applications, but it has been hampered by the tendency of the metal atom to form large clusters. We found, as studied by the state-of-the-art electron microscopic technique, a strategy to produce metal-containing nanoparticles isolated from each other by depositing metal atoms in a hydrophilic hole on or in the interior of a carbon nanotube as demonstrated by the reaction of Gd(OAc)(3) with oxidized single-wall nanohorns. Besides the potential utilities of the deposited metal clusters, the metal deposition protocol provides a method to control permeation of molecules through such openings.

SUBMITTER: Hashimoto A

PROVIDER: S-EPMC423227 | biostudies-literature | 2004 Jun

REPOSITORIES: biostudies-literature

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Selective deposition of a gadolinium(III) cluster in a hole opening of single-wall carbon nanohorn.

Hashimoto Ayako A Yorimitsu Hideki H Ajima Kumiko K Suenaga Kazutomo K Isobe Hiroyuki H Miyawaki Jin J Yudasaka Masako M Iijima Sumio S Nakamura Eiichi E

Proceedings of the National Academy of Sciences of the United States of America 20040526 23

Selective synthesis of particles of angstrom to nanometer size consisting of one to many metal atoms is instrumental in various applications, but it has been hampered by the tendency of the metal atom to form large clusters. We found, as studied by the state-of-the-art electron microscopic technique, a strategy to produce metal-containing nanoparticles isolated from each other by depositing metal atoms in a hydrophilic hole on or in the interior of a carbon nanotube as demonstrated by the reacti ...[more]

PMID: 15163794

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Project description:Background and purposeDose-dependent association between hyperintensity in deep brain structures on unenhanced T1WIs and gadolinium-based contrast agent administrations has been demonstrated with subsequent histopathological confirmation of gadolinium deposition. Our aim was to determine whether greater exposure to linear gadolinium-based contrast agent administration is associated with higher signal intensity in deep brain structures on unenhanced T1-weighted MR imaging. Secondary objective was to compare signal intensity differences between ionic and nonionic linear gadolinium-based contrast agents.Materials and methodsSubjects with secondary-progressive MS originally enrolled in a multicenter clinical trial were studied retrospectively. Eighty subjects (high-exposure cohort) received 9 linear gadolinium-based contrast agent administrations (30 nonionic/50 ionic) between week -4 and year 1 and a tenth administration by year 2. One hundred fifteen subjects (low-exposure cohort) received 2 administrations (40 nonionic/75 ionic) between week -4 and year 1 and a third administration by year 2. Signal intensities were measured on unenhanced T1WIs by placing sample-points on the dentate nucleus, globus pallidus, caudate, thalamus, pons, and white matter, and they were normalized using the following ratios: dentate/pons, globus pallidus/white matter, caudate/white matter, and thalamus/white matter.ResultsBetween week -4 and year 1, subjects in the high-exposure cohort showed increased signal intensity ratios in all regions (P < .01), while the low-exposure cohort showed only an increase in the dentate nucleus (P = .003). Between years 1 and 2, when both cohorts received only 1 additional gadolinium-based contrast agent, no significant changes were observed. In the high-exposure cohort, significantly higher changes in signal intensity ratios were observed in subjects receiving linear nonionic than in those receiving linear ionic gadolinium-based contrast agents.ConclusionsHyperintensity in deep brain structures from gadolinium deposition is related to the number of doses and the type of linear gadolinium-based contrast agent (nonionic greater than ionic) administration.

Dataset Information

Selective deposition of a gadolinium(III) cluster in a hole opening of single-wall carbon nanohorn.

Publications

Selective deposition of a gadolinium(III) cluster in a hole opening of single-wall carbon nanohorn.

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