Ontology highlight
ABSTRACT:
SUBMITTER: He A
PROVIDER: S-EPMC4236193 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
He Aibin A Gu Fei F Hu Yong Y Ma Qing Q Ye Lillian Yi LY Akiyama Jennifer A JA Visel Axel A Pennacchio Len A LA Pu William T WT
Nature communications 20140924
How stage-specific enhancer dynamics modulate gene expression patterns essential for organ development, homeostasis and disease is not well understood. Here, we addressed this question by mapping chromatin occupancy of GATA4--a master cardiac transcription factor--in heart development and disease. We find that GATA4 binds and participates in establishing active chromatin regions by stimulating H3K27ac deposition, which facilitates GATA4-driven gene expression. GATA4 chromatin occupancy changes m ...[more]