Ontology highlight
ABSTRACT:
SUBMITTER: Tuomela J
PROVIDER: S-EPMC4238912 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Tuomela Johanna J Sandholm Jouko J Kaakinen Mika M Patel Ankita A Kauppila Joonas H JH Ilvesaro Joanna J Chen Dongquan D Harris Kevin W KW Graves David D Selander Katri S KS
Breast cancer research and treatment 20131110 3
TLR9 is a cellular DNA-receptor, which is widely expressed in breast and other cancers. Although synthetic TLR9-ligands induce cancer cell invasion in vitro, the role of TLR9 in cancer pathophysiology has remained unclear. We show here that living cancer cells uptake DNA from chemotherapy-killed cancer cells. We discovered that such DNA induces TLR9- and cathepsin-mediated invasion in living cancer cells. To study whether this phenomenon contributes to treatment responses, triple-negative, human ...[more]