Ontology highlight
ABSTRACT:
SUBMITTER: Thiabaud G
PROVIDER: S-EPMC4241752 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Thiabaud Grégory G Arambula Jonathan F JF Siddik Zahid H ZH Sessler Jonathan L JL
Chemistry (Weinheim an der Bergstrasse, Germany) 20140624 29
In an effort to increase the stability and control the platinum reactivity of platinum-texaphyrin conjugates, two Pt(IV) conjugates were designed, synthesized, and studied for their ability to form DNA adducts. They were also tested for their anti-proliferative effects using wild-type and platinum-resistant human ovarian cancer cell lines (A2780 and 2780CP, respectively). In comparison to an analogous first-generation Pt(II) chimera, one of the new conjugates provided increased stability in aque ...[more]