Ontology highlight
ABSTRACT:
SUBMITTER: Thiabaud G
PROVIDER: S-EPMC7132275 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Thiabaud Grégory G He Guangan G Sen Sajal S Shelton Kathryn A KA Baze Wallace B WB Segura Luke L Alaniz Julie J Munoz Macias Ruben R Lyness Greg G Watts Alan B AB Kim Hyun Min HM Lee Hyunseung H Cho Mi Young MY Hong Kwan Soo KS Finch Rick R Siddik Zahid H ZH Arambula Jonathan F JF Sessler Jonathan L JL
Proceedings of the National Academy of Sciences of the United States of America 20200316 13
Described here is the development of gadolinium(III) texaphyrin-platinum(IV) conjugates capable of overcoming platinum resistance by 1) localizing to solid tumors, 2) promoting enhanced cancer cell uptake, and 3) reactivating p53 in platinum-resistant models. Side by side comparative studies of these Pt(IV) conjugates to clinically approved platinum(II) agents and previously reported platinum(II)-texaphyrin conjugates demonstrate that the present Pt(IV) conjugates are more stable against hydroly ...[more]