Ontology highlight
ABSTRACT:
SUBMITTER: Zheng YR
PROVIDER: S-EPMC4303084 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Zheng Yao-Rong YR Suntharalingam Kogularamanan K Johnstone Timothy C TC Lippard Stephen J SJ
Chemical science 20150201 2
This report presents a novel strategy that facilitates delivery of multiple, specific payloads of Pt(IV) prodrugs using a well-defined supramolecular system. This delivery system comprises a hexanuclear Pt(II) cage that can host four Pt(IV) prodrug guest molecules. Relying on host-guest interactions between adamantyl units tethered to the Pt(IV) molecules and the cage, four prodrugs could be encapsulated within one cage. This host-guest complex, exhibiting a diameter of about 3 nm, has been char ...[more]