Ontology highlight
ABSTRACT:
SUBMITTER: Bizarro J
PROVIDER: S-EPMC4242836 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
The Journal of cell biology 20141117 4
In vitro, assembly of box C/D small nucleolar ribonucleoproteins (snoRNPs) involves the sequential recruitment of core proteins to snoRNAs. In vivo, however, assembly factors are required (NUFIP, BCD1, and the HSP90-R2TP complex), and it is unknown whether a similar sequential scheme applies. In this paper, we describe systematic quantitative stable isotope labeling by amino acids in cell culture proteomic experiments and the crystal structure of the core protein Snu13p/15.5K bound to a fragment ...[more]