Ontology highlight
ABSTRACT:
SUBMITTER: McKeegan KS
PROVIDER: S-EPMC2099223 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
McKeegan Kenneth Scott KS Debieux Charles Maurice CM Boulon Séverine S Bertrand Edouard E Watkins Nicholas James NJ
Molecular and cellular biology 20070716 19
The box C/D small nucleolar RNPs (snoRNPs) are essential for the processing and modification of rRNA. The core box C/D proteins are restructured during human U3 box C/D snoRNP biogenesis; however, the molecular basis of this is unclear. Here we show that the U8 snoRNP is also restructured, suggesting that this may occur with all box C/D snoRNPs. We have characterized four novel human biogenesis factors (BCD1, NOP17, NUFIP, and TAF9) which, along with the ATPases TIP48 and TIP49, are likely to be ...[more]