Ontology highlight
ABSTRACT:
SUBMITTER: Mageed SN
PROVIDER: S-EPMC4249369 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Mageed Sarmad N SN Cunningham Fraser F Hung Alvin Wei AW Silvestre Hernani Leonardo HL Wen Shijun S Blundell Tom L TL Abell Chris C McConkey Glenn A GA
Antimicrobial agents and chemotherapy 20140721 11
Toxoplasma gondii is a major food pathogen and neglected parasitic infection that causes eye disease, birth defects, and fetal abortion and plays a role as an opportunistic infection in AIDS. In this study, we investigated pantothenic acid (vitamin B5) biosynthesis in T. gondii. Genes encoding the full repertoire of enzymes for pantothenate synthesis and subsequent metabolism to coenzyme A were identified and are expressed in T. gondii. A panel of inhibitors developed to target Mycobacterium tub ...[more]