Ontology highlight
ABSTRACT:
SUBMITTER: Cabral CM
PROVIDER: S-EPMC4760770 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Cabral Carla M CM Tuladhar Shraddha S Dietrich Hans K HK Nguyen Elizabeth E MacDonald Wes R WR Trivedi Tapasya T Devineni Asha A Koshy Anita A AA
PLoS pathogens 20160219 2
Toxoplasma gondii, a common brain-tropic parasite, is capable of infecting most nucleated cells, including astrocytes and neurons, in vitro. Yet, in vivo, Toxoplasma is primarily found in neurons. In vitro data showing that interferon-γ-stimulated astrocytes, but not neurons, clear intracellular parasites suggest that neurons alone are persistently infected in vivo because they lack the ability to clear intracellular parasites. Here we test this theory by using a novel Toxoplasma-mouse model cap ...[more]