Ontology highlight
ABSTRACT:
SUBMITTER: Doroshenko N
PROVIDER: S-EPMC4249571 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Doroshenko Natalya N Tseng Boo Shan BS Howlin Robert P RP Deacon Jill J Wharton Julian A JA Thurner Philipp J PJ Gilmore Brendan F BF Parsek Matthew R MR Stoodley Paul P
Antimicrobial agents and chemotherapy 20140929 12
Staphylococcus epidermidis biofilm formation is responsible for the persistence of orthopedic implant infections. Previous studies have shown that exposure of S. epidermidis biofilms to sub-MICs of antibiotics induced an increased level of biofilm persistence. BODIPY FL-vancomycin (a fluorescent vancomycin conjugate) and confocal microscopy were used to show that the penetration of vancomycin through sub-MIC-vancomycin-treated S. epidermidis biofilms was impeded compared to that of control, untr ...[more]