Ontology highlight
ABSTRACT:
SUBMITTER: Wagner K
PROVIDER: S-EPMC4250106 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Wagner Koen K Kwakkenbos Mark J MJ Claassen Yvonne B YB Maijoor Kelly K Böhne Martino M van der Sluijs Koenraad F KF Witte Martin D MD van Zoelen Diana J DJ Cornelissen Lisette A LA Beaumont Tim T Bakker Arjen Q AQ Ploegh Hidde L HL Spits Hergen H
Proceedings of the National Academy of Sciences of the United States of America 20141110 47
Bispecific antibodies have therapeutic potential by expanding the functions of conventional antibodies. Many different formats of bispecific antibodies have meanwhile been developed. Most are genetic modifications of the antibody backbone to facilitate incorporation of two different variable domains into a single molecule. Here, we present a bispecific format where we have fused two full-sized IgG antibodies via their C termini using sortase transpeptidation and click chemistry to create a coval ...[more]